Nabil Khater

Advisor

Nabil Khater graduated from Georgia Institute of Technology with a Masters degree in Mechanical Engineering (1986) and with a Masters degree in Medical Physics (1991). He held several positions in radiation oncology Medical Physics in the USA and in Lebanon; Currently, Chief Medical Physicist at the St. Joseph University Hotel-Dieu de France Hospital, Lebanon.

Nabil has been actively involved in project development since 2003.

(2003-2009) Designed and directed the manufacturing of the Radiation Analyzer TM software, in compliance with Good Manufacturing Practice (GMP). The Radiation Analyzer TM is a film dosimetry application for patient-specific QA; currently installed in several locations around the world.

(2003-2006) Developed methods and directed the production of prostate brachytherapy software for conventional TRUS-based pre-planning; post-planning using digital radiography 2D-3D reconstruction of seeds and fusion with CT and/or MRI; and, Intra-operative implant correction using digital radiography 2D-3D reconstruction of seeds and fusion with TRUS.

(2007-2008) Developed methods and directed the production of fiducial gold seeds image-guided radiation therapy (IGRT) software for continuous monitoring and patient repositioning, using real-time KV electronic portal imaging and 2D-3D reconstruction of fiducial seeds coordinates. The software was designed to perform daily and intra-fraction IGRT, and to monitor seed positions during stereotactic ablative body radiosurgery (SABR).

(2008-2012) Developed methods and directed the production of a conventional circular collimator arc radiosurgery planning system. Several milestones of the project have been completed, namely, Imaging import, image registration (or fusion), organ segmentation, structure 3D reconstruction, dose computation, visualization, and evaluation.

(2009) Developed methods and directed the production of film dosimetry software for 3D Verification and Validation for CyberKnife Stereotactic Radio-Surgery (SRS) treatment planning and delivery; also applicable for multi-leaf and circular arc SRS. Functionality is now integrated in the Radiation Analyzer TM

(2009-Present) Nabil is collaborating with Phase2Therapy (P2T), The Hague, The Netherlands to develop image-guided cancer intervention system and tumor response measurement for radioimmunotherapy (RIT) in solid tumors. Many solid tumors have a tumor matrix containing Tenascin-C (TNC), an extracellular matrix glycoprotein. TNC will be targeted by intra-umoral (IT) injection of therapeutic Y-90 radioimmunoconjugate. Aim is to develop new software and imaging protocols to provide treatment planning and dosimetry of IT Y-90 RIT as well as volumetric therapy response measurement for TNC-expressing solid tumors.

Milestones completed so far:

  • Tools for planning system implementations as in the stereotactic project described
  • Monte Carlo simulation of points dose kernel for Y-90 in water equivalent medium
  • Imaging protocols to determine the 3D effective bio-distribution of Y-90 from In-111 sequential SPECT scans
  • (Abstract) Vriesendorp H, Khater N. Innovative Radiolabeled Immunoglobulin Therapy could provide better local regional control in patients with solid tumors. Joint Workshop: Technology for Innovation in Radiation Oncology, National Institutes of Health, Bethesda, MD, June 13 – 14, 2013
  • Joint Workshop: Technology for Innovation in Radiation Oncology, National Institutes of Health, Bethesda, MD, June 13 – 14, 2013

Reason for Joining P2T:

“Despite recent advances in external beam targeting in radiation oncology, no effects on cure or prolonged survival are evident yet for the majority of cancers. Hence, I believe the P2T radio-immunotherapy project is based on sound scientific hypotheses with achievable goals and carries a high potential for the future of cancer care.”